Histatin 1 enhanced the speed and quality of wound healing through regulating the behaviour of fibroblast,Cell Proliferation

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Histatin 1 enhanced the speed and quality of wound healing through regulating the behaviour of fibroblast
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-07-13 , DOI: 10.1111/cpr.13087
Liuhanghang Cheng _{1,

2,

3} , Xiaoxuan Lei _{4,

5} , Zengjun Yang ₆ , Yanan Kong ₇ , Pengcheng Xu ₅ , Shiya Peng ₈ , Jue Wang _{9,

10} , Cheng Chen _{9,

10} , Yunqing Dong _{5,

11} , Xiaohong Hu _{9,

10} , Xiaorong Zhang _{9,

10} , Tymour Forouzanfar ₄ , Gang Wu _{4,

12} , Xiaobing Fu _{1,

2,

3}

Affiliation

Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department and 4th Medical Center, PLA General Hospital and PLA Medical College, Beijing, China.
PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, Beijing, China.
Research Unit of Trauma Care, Tissue Repair and Regeneration, Chinese Academy of Medical Sciences, Beijing, China.
Department of Oral and Maxillofacial Surgery/Pathology, Amsterdam UMC and Academic Center for Dentistry Amsterdam (ACTA), Vrije University Amsterdam (VU), Amsterdam Movement Science, Amsterdam, The Netherlands.
Department of Burn and Plastic Surgery, General Hospital of Southern Theater Command, Guangzhou, China.
Department of Dermatology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Department of Plastic Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Department of Dermatology and Rheumatology Immunology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
State Key Laboratory of Trauma, Burns, and Combined Injury, Institute of Burn Research, The First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing, China.
Chongqing Key Laboratory for Disease Proteomics, Chongqing, China.
The First School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Department of Oral Implantology and Prosthetic Dentistry, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam (UvA) and Vrije Universiteit Amsterdam (VU), Amsterdam, The Netherlands.

Histatin 1(Hst 1) has been proved to promote wound healing. However, there was no specific study on the regulation made by Hst 1 of fibroblasts in the process of wound healing. This research comprehensively studied the regulation of Hst 1 on the function of fibroblasts in the process of wound healing and preliminary mechanism about it.

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