Background

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease. The association between diabetes mellitus and fracture risk is unclear. Currently, T2DM is not an independent risk factor for low-energy fractures in elderly patients. This study aimed to explore the association between T2DM and the risk of hip and vertebral fractures.

Method

PubMed, MEDLINE, and Cochrane library databases were searched for articles on T2DM and fracture risk. The final study sample from the literature was determined using predefined inclusion criteria, and a meta-analysis, including heterogeneity testing, publication bias analysis, and subgroup analysis, of relevant data was undertaken using STATA software.

Results

Seventeen studies, involving 365,185 participants, 6539 hip fracture events, and 1381 vertebral fracture events were included in this research. The adjusted relative risk of T2DM and hip or vertebral fracture were 1.46 (95% confidence interval [CI] 1.31–1.61) and 1.00 (95% CI 0.81–1.18), respectively, which showed that T2DM is positively related to hip fracture although not significantly associated with vertebral fractures.

Conclusion

T2DM was positively associated with an increased risk of hip fracture but not with vertebral fracture. Bone health in patients with T2DM requires more attention, and further research is warranted.

中文翻译：

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2 型糖尿病和髋部和椎骨骨折的风险：队列研究的系统评价和荟萃分析

背景

2 型糖尿病 (T2DM) 是一种慢性代谢性疾病。糖尿病与骨折风险之间的关联尚不清楚。目前，T2DM 不是老年患者低能量骨折的独立危险因素。本研究旨在探讨 T2DM 与髋部和椎体骨折风险之间的关联。

方法

在 PubMed、MEDLINE 和 Cochrane 图书馆数据库中搜索了关于 T2DM 和骨折风险的文章。使用预先定义的纳入标准确定来自文献的最终研究样本，并使用 STATA 软件对相关数据进行荟萃分析，包括异质性检验、发表偏倚分析和亚组分析。

结果

本研究共纳入 17 项研究，涉及 365,185 名参与者、6539 例髋部骨折事件和 1381 例椎骨骨折事件。T2DM 和髋部或椎体骨折的调整后相对风险分别为 1.46（95% 置信区间 [CI] 1.31-1.61）和 1.00（95% CI 0.81-1.18），这表明 T2DM 与髋部骨折呈正相关与椎体骨折密切相关。

结论

T2DM 与髋部骨折风险增加呈正相关，但与椎骨骨折无关。T2DM 患者的骨骼健康需要更多关注，需要进一步研究。