Abstract

Secondary metabolites generated by marine fungi have relatively small molecular weights and excellent activities and have become an important source for developing drug lead compounds. The review summarizes the structures of novel small-molecule compounds derived from marine fungi in recent years; introduces representative monomers in antimicrobial, antitumor, anti-viral, and anti-neuritis aspects; and discusses their biological activities and molecular mechanisms. This review will act as a guide for further discovering marine-derived drugs with novel chemical structures and specific targeting mechanisms.

中文翻译：

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海洋真菌中的天然生物活性化合物（2017-2020）

摘要

海洋真菌产生的次级代谢产物分子量相对较小，活性优良，已成为开发药物先导化合物的重要来源。综述了近年来海洋真菌衍生的新型小分子化合物的结构；介绍了抗菌、抗肿瘤、抗病毒和抗神经炎方面的代表性单体；并讨论了它们的生物活性和分子机制。该综述将作为进一步发现具有新化学结构和特定靶向机制的海洋衍生药物的指南。