Abstract

Background

We quantified the risk of respiratory syncytial virus (RSV) hospitalizations and severe outcomes among children with neurological disorders.

Methods

We estimated RSV-specific and RSV-associated hospitalization rates using International Classification of Diseases, Ninth Revision (ICD-9) codes from 2 insurance claims IBM MarketScan Research Databases (Commercial and Multi-State Medicaid) from July 2006 through June 2015. For comparison, a simple random sample of 10% of all eligible children was selected to represent the general population. Relative rates (RRs) of RSV hospitalization were calculated by dividing rates for children with neurological disorders by rates for children in the general population by age group and season.

Results

The RSV-specific hospitalization rate for children with any neurological condition was 4.2 (95% confidence interval [CI]: 4.1, 4.4) per 1000 person-years, and the RSV-associated hospitalization rate was 7.0 (95% CI: 6.9, 7.2) per 1000 person-years among children <19 years of age. Among privately insured children, the overall RR of RSV hospitalization in children with neurological disorders compared with the general population was 10.7 (95% CI: 10.0, 11.4) for RSV-specific hospitalization and 11.1 (95% CI: 10.5, 11.7) for RSV-associated hospitalizations. Among children in Medicaid, the RSV-specific hospitalization RR was 6.1 (95% CI: 5.8, 6.5) and the RSV-associated hospitalization RR was 6.4 (95% CI: 6.2, 6.7) compared with the general population.

Conclusions

Our population-based study of children with neurological disorders found that the risk of RSV hospitalization was 6 to 12 times higher among children with neurological disorders than among the general pediatric population. These findings should be considered when determining who should be targeted for current and future RSV interventions.

中文翻译：

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2006-2015 年神经系统疾病儿童呼吸道合胞病毒相关住院情况

 抽象的

 背景

我们量化了患有神经系统疾病的儿童因呼吸道合胞病毒 (RSV) 住院和严重后果的风险。

 方法

我们使用 2006 年 7 月至 2015 年 6 月期间 IBM MarketScan 研究数据库（商业和多州医疗补助）的 2 项保险索赔的国际疾病分类第九版 (ICD-9) 代码估算了 RSV 特异性和 RSV 相关住院率。 ，从所有符合条件的儿童中选择 10% 的简单随机样本来代表一般人群。 RSV 住院的相对率 (RR) 是通过将患有神经系统疾病的儿童的比率除以按年龄组和季节划分的一般人群中儿童的比率来计算的。

 结果

患有任何神经系统疾病的儿童的 RSV 特异性住院率为每 1000 人年 4.2 例（95% 置信区间 [CI]：4.1，4.4），RSV 相关住院率为 7.0 例（95% CI：6.9，7.2） ) 每 1000 人年 <19 岁儿童。在私人保险儿童中，与普通人群相比，患有神经系统疾病的儿童因 RSV 住院的总体 RR 为 10.7（95% CI：10.0，11.4），RSV 特异性住院为 10.7（95% CI：10.0，11.4），RSV 为 11.1（95% CI：10.5，11.7） -相关的住院治疗。与一般人群相比，参加医疗补助的儿童中，RSV 特异性住院 RR 为 6.1 (95% CI: 5.8, 6.5)，RSV 相关住院 RR 为 6.4 (95% CI: 6.2, 6.7)。

 结论

我们对患有神经系统疾病的儿童进行的基于人群的研究发现，患有神经系统疾病的儿童因 RSV 住院的风险比一般儿科人群高 6 至 12 倍。在确定当前和未来 RSV 干预措施的目标对象时应考虑这些发现。