Introduction cardiovascular disease (CVD) and chronic inflammation are implicated in the development of frailty. Longitudinal analyses of inflammatory markers, biomarkers of cardiac dysfunction and incidence of frailty are limited. Methods in the British Regional Heart Study, 1,225 robust or pre-frail men aged 71–92 years underwent a baseline examination, with questionnaire-based frailty assessment after 3 years. Frailty definitions were based on the Fried phenotype. Associations between incident frailty and biomarkers of cardiac dysfunction (high-sensitivity cardiac troponin T (hs-cTnT), N-terminal pro B-type natriuretic peptide (NT-proBNP)) and inflammation (C-reactive protein (CRP) and interleukin-6 (IL-6)) were examined, by tertile, with the lowest as reference. Results follow-up data were available for 981 men. Ninety one became frail. Adjusted for age, pre-frailty, prevalent and incident CVD, comorbidity, polypharmacy and socioeconomic status, IL-6 (third tertile OR 2.36, 95% CI 1.07–5.17) and hs-cTnT (third tertile OR 2.24, 95% CI 1.03–4.90) were associated with increased odds of frailty. CRP (third tertile OR 1.83, 95% CI 0.97–4.08) and NT-proBNP (second tertile OR 0.48, 95% CI 0.23–1.01) showed no significant association with incident frailty. The top tertiles of CRP, IL-6, hscTnT and NT-proBNP were strongly associated with mortality prior to follow-up. Conclusion IL-6 is associated with incident frailty, supporting the prevailing argument that inflammation is involved in the pathogenesis of frailty. Cardiomyocyte injury may be associated with frailty risk. Associations between elevated CRP and frailty cannot be fully discounted; NT-proBNP may have a non-linear relationship with incident frailty. CRP, IL-6, hs-cTnT and NT-proBNP are vulnerable to survivorship bias.

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炎症、心血管生物标志物和事件衰弱之间的关联：英国区域心脏研究

心血管疾病 (CVD) 和慢性炎症与衰弱的发展有关。炎症标志物、心功能不全的生物标志物和虚弱发生率的纵向分析是有限的。在英国区域心脏研究的方法中，1,225 名年龄在 71-92 岁的健壮或体弱前的男性接受了基线检查，并在 3 年后进行了基于问卷的虚弱评估。虚弱定义基于 Fried 表型。突发性虚弱与心脏功能障碍生物标志物（高敏心肌肌钙蛋白 T (hs-cTnT)、N 端 B 型利钠肽前体 (NT-proBNP)）和炎症（C 反应蛋白 (CRP) 和白细胞介素- 6 (IL-6)) 按三分位数进行检查，最低值作为参考。结果 981 名男性可获得随访数据。九十一变得虚弱。根据年龄、衰弱前、流行和事件 CVD、合并症、多种药物和社会经济状况、IL-6（第三三分位数 OR 2.36, 95% CI 1.07–5.17）和 hs-cTnT（第三三分位数 OR 2.24, 95% CI 1.03）进行调整–4.90) 与虚弱几率增加有关。CRP（第三个三分位数 OR 1.83, 95% CI 0.97-4.08）和 NT-proBNP（第二个三分位数 OR 0.48, 95% CI 0.23-1.01）显示与事件衰弱没有显着相关性。CRP、IL-6、hscTnT 和 NT-proBNP 的前三分位数与随访前的死亡率密切相关。结论 IL-6 与衰弱事件相关，支持炎症与衰弱发病机制有关的普遍论点。心肌细胞损伤可能与虚弱风险有关。CRP 升高与虚弱之间的关联不能被完全忽视；NT-proBNP 可能与事件衰弱具有非线性关系。CRP、IL-6、hs-cTnT 和 NT-proBNP 容易受到生存偏差的影响。