Focal impaired awareness seizures (FIASs) are the most common seizure type in adults and are often refractory to medication. Management of FIASs is clinically challenging, and new interventions are needed for better seizure control. The amygdala-kindling model is a preclinical model of FIASs with secondary generalization. The present study assessed the efficacy of cannabidiol (CBD), ∆9-tetrahydrocannabinol (THC), and a combination of CBD and THC in a 15:1 ratio at suppressing focal and secondarily generalized seizures in the amygdala-kindled rat.

中文翻译：

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大麻素在杏仁核点燃模型中的抗癫痫作用

局灶性意识障碍癫痫发作 (FIAS) 是成人最常见的癫痫发作类型，并且通常对药物无效。FIAS 的管理在临床上具有挑战性，需要新的干预措施来更好地控制癫痫发作。杏仁核点燃模型是具有二次泛化的 FIAS 的临床前模型。本研究评估了大麻二酚 (CBD)、Δ9-四氢大麻酚 (THC) 以及 CBD 和 THC 以 15:1 的比例组合在抑制杏仁核点燃的大鼠局灶性和继发性全身性癫痫发作方面的功效。