Potential endpoint biomarkers were evaluated in the assessment of exposure to triazoles, in the southern region of Minas Gerais, Brazil. Volunteers were divided into three groups: occupationally exposed and rural residents (n = 21), non-occupationally exposed and rural residents (n = 35) and non-occupationally exposed and urban residents (n = 30). Of all endpoints evaluated, plasma concentration of androstenedione (p < 0.001) and glycine-conjugated bile acids presented statistical differences in the three studied groups (p < 0.05). However, our findings concerning oxidative stress and testosterone levels, plus that related to unconjugated and taurine conjugated bile acids, suggested that more studies are necessary to evaluate their potential as biomarkers for triazole exposure, as statistical significance was not attained between the groups. Our human population data contributes to the development of triazole exposure risk assessment with respect to these potential effect biomarkers, in potentially vulnerable groups and individuals.

在巴西米纳斯吉拉斯州南部地区的三唑类暴露评估中评估了潜在的终点生物标志物。志愿者被分为三组：职业暴露和农村居民（n = 21）、非职业暴露和农村居民（n = 35）和非职业暴露和城市居民（n = 30）。在所有评估的终点中，雄烯二酮 ( p < 0.001) 和甘氨酸结合胆汁酸的血浆浓度在三个研究组中呈现出统计学差异 ( p< 0.05)。然而，我们关于氧化应激和睾酮水平的发现，以及与未结合和牛磺酸结合胆汁酸相关的研究结果表明，需要更多的研究来评估它们作为三唑暴露生物标志物的潜力，因为两组之间没有达到统计学意义。我们的人口数据有助于在潜在脆弱群体和个人中针对这些潜在影响生物标志物开展三唑暴露风险评估。