Hearing loss is often caused by death of sensory hair cells (HCs) in the inner ear. HCs are vulnerable to some ototoxic drugs, such as aminoglycosides(AGs) and the cisplatin.The most predominant form of drug-induced cell death is apoptosis. Many efforts have been made to protect HCs from cell death after ototoxic drug exposure. These mechanisms and potential targets of HCs protection will be discussed in this review.And we also propose further investigation in the field of HCs necrosis and regeneration, as well as future clinical utilization.

中文翻译：

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耳毒性药物对毛细胞的保护

听力损失通常是由内耳感觉毛细胞 (HC) 的死亡引起的。HCs易受一些耳毒性药物的影响，如氨基糖苷类（AGs）和顺铂。药物诱导的细胞死亡最主要的形式是细胞凋亡。已经进行了许多努力来保护 HC 在耳毒性药物暴露后免于细胞死亡。本文将对这些保护HCs的机制和潜在靶点进行讨论，并提出在HCs坏死和再生领域的进一步研究，以及未来的临床应用。