Background. Although the relationship between gout and cardiovascular has been well demonstrated, there is little information about the difference between gout with cerebrovascular disease and cardiovascular disease. In this study, the differences between gout with cerebral infarction (gout+CI) and gout with coronary heart disease (gout+CHD) and related factors that affect serum uric acid (sUA) levels in gout+CI were investigated by a cross-sectional study. Method. The patients from Jiangxi Provincial People’s Hospital with gout+CHD, gout+CI, and gout with coronary heart disease and cerebral infarction (gout+CHD+CI) between 2016 and 2020 were included in this study, and the medical record data were collected and analyzed. Results. We observed significant differences in age, drinking, hypertension, long-term use of diuretics and NSAIDs, sUA, CRE, and blood glucose in patients with gout+CHD and gout+CI. The sUA level was significantly positively correlated with smoking, CRE, and TG in the gout+CI group and was only positively correlated with CRE in the gout+CHD group and the gout+CHD+CI group (). Interestingly, the sUA level was only negatively correlated with the age and gender in the gout+CI group (). After excluding factors with no significant statistical effect, only age, gender, smoking, CRE, and TG were included in the multiple linear regression model. It suggested that smoking, CRE, and TG are positively correlated with the sUA level, while age was negatively correlated with the sUA level. Conclusions. There are many discrepancies in clinical characteristics between gout+CHD patients and gout+CI patients, especially that the factors that affect UA levels are significantly different. The data also suggested that uric acid-lowering therapy may need to be strengthened in the young gout+CI patients with a history of smoking.

中文翻译：

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脑梗死痛风患者血尿酸的影响因素

背景。尽管痛风与心血管疾病之间的关系已得到很好的证明，但关于痛风与脑血管疾病和心血管疾病之间的区别的信息很少。本研究通过横断面调查研究痛风合并脑梗死（痛风+CI）与痛风合并冠心病（痛风+CHD）的差异及影响痛风+CI中血清尿酸（sUA）水平的相关因素。学习。方法。将2016-2020年江西省人民医院痛风+CHD、痛风+CI、痛风合并冠心病脑梗死（gout+CHD+CI）患者纳入本研究，收集病历资料，分析了。结果. 我们观察到痛风+CHD 和痛风+CI 患者的年龄、饮酒、高血压、长期使用利尿剂和非甾体抗炎药、sUA、CRE 和血糖存在显着差异。痛风+CI组sUA水平与吸烟、CRE、TG呈显着正相关，仅与痛风+CHD组和痛风+CHD+CI组CRE呈正相关。）。有趣的是，sUA 水平仅与痛风+CI 组的年龄和性别呈负相关（）。剔除无显着统计学影响的因素后，多元线性回归模型仅包括年龄、性别、吸烟、CRE和TG。这表明吸烟、CRE和TG与sUA水平呈正相关，而年龄与sUA水平呈负相关。结论。痛风+CHD患者与痛风+CI患者的临床特征存在诸多差异，尤其是影响UA水平的因素存在显着差异。数据还表明，有吸烟史的年轻痛风+CI患者可能需要加强降尿酸治疗。