Objectives:

We analyzed the magnetic resonance imaging (MRI) manifestations of fetal corpus callosum abnormalities and discussed their prognosis based on the results of postnatal follow up.

Methods:

One hundred fifty-five fetuses were diagnosed with corpus callosum abnormalities by MRI at our hospital from 2004 to 2019. Gesell Development Scales were used to evaluate the prognosis of corpus callosum abnormalities after birth.

Results:

Corpus callosum abnormalities were diagnosed in 149 fetuses from singleton pregnancies, and 6 pairs of twins, 1 in each pair is a corpus callosum abnormality. Twenty-seven cases (27/155) were lost to follow up, whereas 128 cases (128/155) were followed up. Of these, 101 cases were induced for labor, whereas 27 cases were born naturally. Among the 27 cases of corpus callosum abnormality after birth, 22 cases were from singleton pregnancies (22/27). Moreover, 1 twin from each of 5 pairs of twins (5/27) demonstrated corpus callosum abnormalities. The average Gesell Development Scale score was 87.1 in 19 cases of agenesis of the corpus callosum and 74.9 in 3 cases of hypoplasia of the corpus callosum. Among the 5 affected twins, 2 had severe neurodevelopmental delay, 2 had mild neurodevelopmental delay, and 1 was premature and died.

Conclusion:

The overall prognosis of agenesis of the corpus callosum is good in singleton pregnancies. Hypoplasia of the corpus callosum is often observed with other abnormalities, and the development quotient of hypoplasia of the corpus callosum is lower compared with agenesis of the corpus callosum. Corpus callosum abnormalities may occur in one twin, in whom the risk may be increased.

中文翻译：

---

胎儿胼胝体异常的磁共振成像（MRI）诊断及随访分析

目标：

我们分析了胎儿胼胝体异常的磁共振成像（MRI）表现，并根据产后随访结果讨论其预后。

方法：

2004-2019年我院155例胎儿经MRI诊断为胼胝体异常。采用Gesell发育量表评价出生后胼胝体异常的预后。

结果：

单胎妊娠149例胎儿，6对双胞胎，每对1例胼胝体异常。27例（27/155）失访，128例（128/155）随访。其中引产101例，自然分娩27例。27例出生后胼胝体异常中，22例为单胎妊娠（22/27）。此外，5对双胞胎中的1对双胞胎（5/27）表现出胼胝体异常。19例胼胝体发育不全的Gesell Development Scale评分平均为87.1分，3例胼胝体发育不全的病例平均为74.9分。5例受累双胞胎中，2例神经发育严重延迟，2例轻度神经发育迟缓，1例早产死亡。

结论：

单胎妊娠胼胝体发育不全的总体预后良好。胼胝体发育不全常伴有其他异常，与胼胝体发育不全相比，胼胝体发育不全的发育商较低。胼胝体异常可能发生在一对双胞胎中，其风险可能会增加。