Canine cutaneous lymphoma is an uncommon lymphoma in dogs. Most canine cutaneous lymphoma cases have a T-cell origin. Canine cutaneous T-cell lymphoma (CTCL) is classified into epitheliotropic and nonepitheliotropic cutaneous lymphomas, and each type of lymphoma is subclassified into several histological subtypes. Limited information is available regarding the prognostic significance of clinical variables and histopathological subtypes in dogs with CTCL. This retrospective study aimed to investigate the influence of clinical variables and histopathological subtypes on the prognosis of dogs with CTCL. Forty-six dogs diagnosed with CTCL by histopathological examination were included. Histopathological specimens were reexamined and classified into CTCL subtypes. The influence of the type of skin lesion, histopathological subtype, haematological examination results and treatment response on the overall survival time (OS) was examined. Thirty-one dogs were diagnosed with epitheliotropic CTCL (mycosis fungoides in 28 dogs; pagetoid reticulosis in 3 dogs) and 15 dogs were diagnosed with nonepitheliotropic CTCL (anaplastic large T-cell lymphoma in 6 dogs; peripheral T-cell lymphoma, not otherwise specified, in 9 dogs). The OS of dogs diagnosed with epitheliotropic CTCL (141 days) was significantly shorter than that of dogs diagnosed with nonepitheliotropic CTCL (374 days). As clinical variables, the presence of neoplastic lymphocytes in peripheral blood, thrombocytopenia and initial chemotherapeutic response was related to prognosis. Our results demonstrated that histopathological subtype and several clinical variables were found to influence the prognosis of dogs with CTCL.

中文翻译：

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犬嗜上皮性和非嗜上皮性皮肤 T 细胞淋巴瘤的结果和预后因素

犬皮肤淋巴瘤是一种罕见的犬淋巴瘤。大多数犬皮肤淋巴瘤病例有 T 细胞起源。犬皮肤 T 细胞淋巴瘤 (CTCL) 分为嗜上皮性和非嗜上皮性皮肤淋巴瘤，每种类型的淋巴瘤又细分为几个组织学亚型。关于 CTCL 犬临床变量和组织病理学亚型的预后意义的信息有限。这项回顾性研究旨在调查临床变量和组织病理学亚型对患有 CTCL 的犬预后的影响。包括通过组织病理学检查诊断为 CTCL 的 46 只狗。重新检查组织病理学标本并将其分类为 CTCL 亚型。皮损类型、组织病理学亚型的影响，检查血液学检查结果和治疗反应对总生存时间（OS）的影响。31 只狗被诊断为嗜上皮性 CTCL（28 只狗为蕈样真菌病；3 只狗为佩吉特样网状组织病），15 只狗被诊断为非嗜上皮性 CTCL（6 只狗为间变性大 T 细胞淋巴瘤；外周 T 细胞淋巴瘤，未另行说明） ，在 9 只狗中）。诊断为嗜上皮性 CTCL 的犬的 OS（141 天）明显短于诊断为非嗜上皮性 CTCL 的犬（374 天）。作为临床变量，外周血中肿瘤淋巴细胞的存在、血小板减少和初始化疗反应与预后有关。我们的研究结果表明，组织病理学亚型和几个临床变量被发现会影响患有 CTCL 的狗的预后。