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Bone-forming perivascular cells: Cellular heterogeneity and use for tissue repair
STEM CELLS ( IF 4.0 ) Pub Date : 2021-07-12 , DOI: 10.1002/stem.3436 Jiajia Xu 1 , Yiyun Wang 1 , Mario A Gomez-Salazar 1 , Ginny Ching-Yun Hsu 1 , Stefano Negri 1 , Zhao Li 1 , Winters Hardy 2 , Lijun Ding 3, 4, 5 , Bruno Peault 2, 5 , Aaron W James 1
STEM CELLS ( IF 4.0 ) Pub Date : 2021-07-12 , DOI: 10.1002/stem.3436 Jiajia Xu 1 , Yiyun Wang 1 , Mario A Gomez-Salazar 1 , Ginny Ching-Yun Hsu 1 , Stefano Negri 1 , Zhao Li 1 , Winters Hardy 2 , Lijun Ding 3, 4, 5 , Bruno Peault 2, 5 , Aaron W James 1
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Mesenchymal progenitor cells are broadly distributed across perivascular niches—an observation conserved between species. One common histologic zone with a high frequency of mesenchymal progenitor cells within mammalian tissues is the tunica adventitia, the outer layer of blood vessel walls populated by cells with a fibroblastic morphology. The diversity and functions of (re)generative cells present in this outermost perivascular niche are under intense investigation; we have reviewed herein our current knowledge of adventitial cell potential with a somewhat narrow focus on bone formation. Antigens of interest to functionally segregate adventicytes are discussed, including CD10, CD107a, aldehyde dehydrogenase isoforms, and CD140a, among others. Purified adventicytes (such as CD10+, CD107alow, and CD140a+ cells) have stronger osteogenic potential and promote bone formation in vivo. Recent bone tissue engineering applications of adventitial cells are also presented. A better understanding of perivascular progenitor cell subsets may represent a beneficial advance for future efforts in tissue repair and bioengineering.
中文翻译：
骨形成血管周围细胞：细胞异质性和用于组织修复
间充质祖细胞广泛分布在血管周围的生态位中——这一观察在物种之间是保守的。在哺乳动物组织中具有高频率间充质祖细胞的一个常见组织学区域是外膜，血管壁的外层由具有成纤维细胞形态的细胞组成。在这个最外层的血管周围生态位中存在的（再生）细胞的多样性和功能正在接受深入研究。我们在这里回顾了我们目前对外膜细胞潜力的了解，但对骨形成的关注有些狭窄。讨论了功能分离外膜细胞感兴趣的抗原，包括 CD10、CD107a、醛脱氢酶同种型和 CD140a 等。纯化的外膜细胞（如 CD10 +, CD107a低, 和 CD140a +细胞) 具有更强的成骨潜力并促进体内骨形成。还介绍了外膜细胞最近的骨组织工程应用。更好地了解血管周围祖细胞亚群可能代表未来组织修复和生物工程努力的有益进展。
更新日期：2021-07-12
中文翻译：
骨形成血管周围细胞：细胞异质性和用于组织修复
间充质祖细胞广泛分布在血管周围的生态位中——这一观察在物种之间是保守的。在哺乳动物组织中具有高频率间充质祖细胞的一个常见组织学区域是外膜，血管壁的外层由具有成纤维细胞形态的细胞组成。在这个最外层的血管周围生态位中存在的（再生）细胞的多样性和功能正在接受深入研究。我们在这里回顾了我们目前对外膜细胞潜力的了解，但对骨形成的关注有些狭窄。讨论了功能分离外膜细胞感兴趣的抗原，包括 CD10、CD107a、醛脱氢酶同种型和 CD140a 等。纯化的外膜细胞（如 CD10 +, CD107a低, 和 CD140a +细胞) 具有更强的成骨潜力并促进体内骨形成。还介绍了外膜细胞最近的骨组织工程应用。更好地了解血管周围祖细胞亚群可能代表未来组织修复和生物工程努力的有益进展。
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