Alternariasin A (1), one new cytochalasin possessing the benzo[4,5]indeno[2,1-d]isoindole-1,3,13(2H,3aH)-trione skeleton, and five known compounds 2−6 were isolated from the solid cultures of the Midui Glacier-derived fungus Alternaria alternata. Their structures were elucidated by NMR and MS spectroscopic analyses and by a comparison with data from the literature. The absolute configuration of 1 was assigned by combination of experimental and calculated electronic circular dichroism (ECD) spectra. Compound 1 displayed antibacterial activity against the S. aureus, B. subtilis and E. coli with MIC values of 16.7, 16.7 and 33.3 μΜ, respectively. While compound 3 showed potent cytotoxicity against a small panel of human tumour cell lines.

Alternariasin A ( 1 )，一种具有苯并[4,5]茚并[2,1- d ]异吲哚-1,3,13(2 H ,3a H )-三酮骨架的新细胞松弛素，以及五种已知化合物2 − 6从米堆冰川衍生的真菌Alternaria alternata的固体培养物中分离出来。通过 NMR 和 MS 光谱分析以及与文献数据的比较，阐明了它们的结构。1的绝对构型由实验和计算的电子圆二色性 (ECD) 光谱的组合指定。化合物1显示出对金黄色葡萄球菌的抗菌活性，枯草杆菌和大肠杆菌的 MIC 值分别为 16.7、16.7 和 33.3 μM。而化合物3对一小部分人类肿瘤细胞系显示出强大的细胞毒性。