The European Physical Journal Plus ( IF 2.8 ) Pub Date : 2021-07-12 , DOI: 10.1140/epjp/s13360-021-01730-3 Ivana Pajic-Lijakovic 1 , Milan Milivojevic 1
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Abstract
Although collective cell migration (CCM) is a highly coordinated migratory mode, perturbations in the form of jamming state transitions and vice versa often occur even in 2D. These perturbations are involved in various biological processes, such as embryogenesis, wound healing, and cancer invasion. CCM induces accumulation of cell residual stress, which has a feedback impact to cell packing density. Density-mediated change of cell mobility influences the state of viscoelasticity of multicellular systems and on that base the jamming state transition. Although a good comprehension of how cells collectively migrate by following molecular rules has been generated, the impact of cellular rearrangements on cell viscoelasticity remains less understood, thus considering that the density-driven evolution of viscoelasticity caused by reduction of cell mobility could result in a powerful tool in order to address the contribution of cell jamming state transition in CCM and help to understand this important but still a controversial topic. In this work a review of existing literature in CCM modeling is given along with an assortment of published experimental findings, in order to invite experimentalists to test the given theoretical considerations in multicellular systems. In addition, five viscoelastic states gained within three regimes: (1) convective regime, (2) conductive regime, and (3) damped-conductive regime, which were discussed with special emphasis of jamming and unjamming states.
Graphic abstract
中文翻译：
粘弹性和细胞干扰状态转换
摘要
尽管集体细胞迁移 (CCM) 是一种高度协调的迁移模式，但即使在 2D 中也经常发生干扰状态转换形式的扰动，反之亦然。这些扰动涉及各种生物过程，例如胚胎发生、伤口愈合和癌症侵袭。CCM 诱导细胞残余应力的积累，这对细胞堆积密度有反馈影响。密度介导的细胞移动性变化影响多细胞系统的粘弹性状态，并在此基础上干扰状态转换。尽管已经对细胞如何通过遵循分子规则集体迁移有了很好的理解，但细胞重排对细胞粘弹性的影响仍然知之甚少，因此，考虑到由细胞移动性降低引起的粘弹性密度驱动的演变可能会成为一个强大的工具，以解决 CCM 中细胞干扰状态转变的贡献，并有助于理解这一重要但仍然是一个有争议的话题。在这项工作中，对 CCM 建模中的现有文献进行了回顾，并提供了各种已发表的实验结果，以邀请实验者在多细胞系统中测试给定的理论考虑。此外，在三种状态下获得了五种粘弹性状态：(1) 对流状态，(2) 导电状态和 (3) 阻尼导电状态，特别强调了干扰和非干扰状态。为了邀请实验者在多细胞系统中测试给定的理论考虑。此外，在三种状态下获得了五种粘弹性状态：（1）对流状态，（2）导电状态和（3）阻尼导电状态，特别强调了干扰和非干扰状态。为了邀请实验者在多细胞系统中测试给定的理论考虑。此外，在三种状态下获得了五种粘弹性状态：（1）对流状态，（2）导电状态和（3）阻尼导电状态，特别强调了干扰和非干扰状态。
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