Human longevity may be found in single individuals as well as in the population as a whole (“population longevity”). Longevity Blue Zones (LBZs), which are areas with an unusually high number of oldest old, have been identified in Sardinia and the Greek island of Ikaria. We compared the lifestyle, health status and some genetic markers of the LBZ populations with those of reference populations from Italy and Greece; the data were extracted from the GEHA database. In the LBZs, the proportion of individuals who never married or were married and still living with their spouse was significantly greater. Nonagenarians males and females with a high self‒perception of optimism and/or a high score for self-rated health were also found in larger proportions in LBZs. Among the variables with lower frequency were the proportion of the widowed, the percentage of subjects who had suffered a stroke and the frequency of Apoε4 and Apoε2 and the TT genotype of FOXO3A gene. Compared to behavioral and health indicators, the impact of genetic factors might be relatively less important in the LBZs. Nevertheless, further research is needed to identify potential epigenetic traits that might play a predominant role due to the interaction between genetics and the human and physical environments.

人类寿命可以在单个个体以及整个人口中找到（“人口寿命”）。长寿蓝区在撒丁岛和希腊的伊卡利亚岛发现了（LBZ），这些地区的最古老的老人数量异常多。我们将LBZ人群的生活方式、健康状况和一些遗传标记与意大利和希腊的参考人群进行了比较；数据是从 GEHA 数据库中提取的。在 LBZ 中，未婚或已婚但仍与配偶同住的个人比例明显更高。在 LBZ 中，自我感觉乐观和/或自评健康得分较高的九龄男性和女性也占较大比例。频率较低的变量包括丧偶比例、中风受试者百分比以及 Apoε4 和 Apoε2 的频率以及 FOXO3A 基因的 TT 基因型。与行为和健康指标相比，遗传因素的影响在 LBZ 中可能相对不那么重要。然而，需要进一步的研究来确定由于遗传学与人类和物理环境之间的相互作用而可能发挥主要作用的潜在表观遗传特征。