Journal of Asian Natural Products Research ( IF 1.7 ) Pub Date : 2021-07-12 , DOI: 10.1080/10286020.2021.1948535 Yong Qian 1 , Chun-Ping Yang 2 , Ping Weng 1 , Min Zhang 2 , Xue-Ge Pan 1 , Yan-Mei Wang 2 , Hua-Bao Chen 2
Abstract
Five compounds were identified from Tripterygium wilfordii, including two novel compounds and three previously known compounds. Two newly discovered compounds are celangulin CY (1α,2α,3β,4β,6β,8α,13-hepacetoxy-9β-benzoyloxy-β-dihydroagarofuran) and celangulin CQ (1α-nicotinoyloxy-2α,3β,6β-triacetoxy-9β-furancarbonyloxy-13-isobutanoyloxy-4β-hydroxy-β-dihydroagarofuran). Their structures were determined using nuclear magnetic resonance (NMR), mass spectrometry (MS), and high-pressure liquid chromatography (HPLC). The isolated compounds were tested for insecticidal activity against the third instar larvae of Spodoptera frugiperda. Both celangulin CY and celangulin CQ exhibited significantly higher oral toxicity in the larvae than that exhibited by the three known compounds.
中文翻译:
雷公藤杀虫化合物的分离与结构鉴定
摘要
从雷公藤中鉴定出五种化合物,包括两种新化合物和三种以前已知的化合物。两种新发现的化合物是 celangulin CY (1α,2α,3β,4β,6β,8α,13-hepacetoxy-9β-benzoyloxy-β-dihydroagarofuran) 和 celangulin CQ (1α-nicotinoyloxy-2α,3β,6β-triacetoxy-9β-呋喃羰氧基-13-异丁酰氧基-4β-羟基-β-二氢琼脂呋喃)。使用核磁共振 (NMR)、质谱 (MS) 和高压液相色谱 (HPLC) 确定它们的结构。测试了分离的化合物对草地夜蛾第三龄幼虫的杀虫活性。celangulin CY 和 celangulin CQ 在幼虫中表现出比这三种已知化合物表现出的更高的口服毒性。