The inhibitory mechanisms of artemisinin anti-algae sustained-release granules (AASG) on algal cells at cytoplasmic level were investigated. The results showed that 0.2 g L⁻¹ AASG could effectively inhibit the growth of Microcystis aeruginosa (M.aeruginosa). The stress of 0.2 g L⁻¹ AASG changed the excitation energy distribution pattern of Photosystem II (PSII) of algal cells, which showed the increase of heat dissipation share and the inhibition of physiological activities related to PSII. At the same time, AASG induced a large amount of reactive oxygen species (ROS), which aggravated the membrane lipid peroxidation and caused serious damage to algae cell membrane. AASG also resulted in the decrease of esterase activity and alkaline phosphatase activity (APA) in algal cells. Results showed that AASG inhibited algal growth by exerting adverse effects on PSII, ROS and metabolic activity of M.aeruginosa.

研究了青蒿素抗藻缓释颗粒（AASG）在细胞质水平对藻类细胞的抑制机制。结果表明：用0.2克L- ^-1 AASG能有效抑制其生长的铜绿微囊藻（微囊藻）。0.2 g L ^-1的应力AASG改变了藻类细胞光系统II（PSII）的激发能分布模式，表现为散热份额增加，PSII相关生理活动受到抑制。同时，AASG诱导了大量活性氧（ROS）的产生，加剧了膜脂过氧化，对藻类细胞膜造成严重破坏。AASG 还导致藻类细胞中酯酶活性和碱性磷酸酶活性 (APA) 的降低。结果表明，AASG通过施加于PSII，ROS和代谢活动产生不利影响抑制藻类生长的铜绿微囊藻。