In the last decade, graphene oxide-based nanomaterials, such as graphene oxide (GO) and reduced graphene oxide (rGO), have attracted more and more attention in the field of biomedicine. Due to the versatile surface functionalization, ultra-high surface area, and excellent biocompatibility of graphene oxide-based nanomaterials, which hold better promise for potential applications than among other nanomaterials in biomedical fields including drug/gene delivery, biomolecules detection, tissue engineering, especially in cancer treatment. Here, we review the recent progress of graphene oxide-based multifunctional nanomaterials for cancer treatment. A comprehensive and in-depth depiction of unique property of graphene oxide-based multifunctional nanomaterials is first interpreted, with particular descriptions about the suitability for applying in cancer therapy. Afterward, recently emerging representative applications of graphene oxide-based multifunctional nanomaterials in antitumor therapy, including as an ideal carrier for drugs/genes, phototherapy, and bioimaging, are systematically summarized. Then, the biosafety of the graphene oxide-based multifunctional nanomaterials is reviewed. Finally, the conclusions and perspectives on further advancing the graphene oxide-based multifunctional nanomaterials toward potential and versatile development for fundamental researches and nanomedicine are proposed.

中文翻译：

---

基于氧化石墨烯的多功能纳米材料用于癌症治疗的最新进展

在过去的十年中，基于氧化石墨烯的纳米材料，如氧化石墨烯（GO）和还原氧化石墨烯（rGO），在生物医学领域引起了越来越多的关注。由于基于氧化石墨烯的纳米材料具有多功能的表面功能化、超高的表面积和优异的生物相容性，在药物/基因递送、生物分子检测、组织工程等生物医学领域中比其他纳米材料具有更好的潜在应用前景，尤其是在癌症治疗中。在这里，我们回顾了基于氧化石墨烯的多功能纳米材料用于癌症治疗的最新进展。首先对基于氧化石墨烯的多功能纳米材料的独特性能进行全面深入的描述，对应用于癌症治疗的适用性进行了特别说明。随后，系统总结了最近出现的基于氧化石墨烯的多功能纳米材料在抗肿瘤治疗中的代表性应用，包括作为药物/基因、光疗和生物成像的理想载体。然后，综述了基于氧化石墨烯的多功能纳米材料的生物安全性。最后，提出了进一步推动基于氧化石墨烯的多功能纳米材料朝着基础研究和纳米医学的潜力和多功能发展方向发展的结论和展望。被系统地总结。然后，综述了基于氧化石墨烯的多功能纳米材料的生物安全性。最后，提出了进一步推动基于氧化石墨烯的多功能纳米材料朝着基础研究和纳米医学的潜力和多功能发展方向发展的结论和前景。被系统地总结。然后，综述了基于氧化石墨烯的多功能纳米材料的生物安全性。最后，提出了进一步推动基于氧化石墨烯的多功能纳米材料朝着基础研究和纳米医学的潜力和多功能发展方向发展的结论和前景。