Hyaluronic acid can lubricate joints, regulate protein translocation, and promote wound healing. In addition, hyaluronidase is a participant in type I allergic reactions, which has a strong correlation with inflammation and allergy. Therefore, inhibiting hyaluronidase activity can not only maintain normal body physiological functions but also achieve antiallergic effects. Given the low-value utilization of Atlantic salmon processing wastes, this study focuses on developing a value-added way to treat salmon byproducts using an enzymatic technology and the hydrolysis parameters were optimized by single-factor experiments and Box–Behnken design, which attain mass production of the peptide with hyaluronidase inhibitory efficiency. The optimal parameters were solid–liquid ratio 1:14.793, pepsin added amount 1.078%, and enzymatic hydrolysis time 7.18 h. The actual peptide yield and anti-hyaluronidase activity were 41.37% and 63.23%, respectively. This provides a reference for the preparation of commercial salmon peptide powder as a food nutrition fortifier and hyaluronidase inhibitor in pharmaceutical, health care, and cosmetic applications.

中文翻译：

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鲑鱼加工副产物制备具有抗过敏作用的透明质酸酶抑制水解物的工艺优化

透明质酸可以润滑关节，调节蛋白质易位，促进伤口愈合。此外，透明质酸酶是I型过敏反应的参与者，与炎症和过敏有很强的相关性。因此，抑制透明质酸酶活性不仅可以维持机体正常生理机能，还可以达到抗过敏作用。鉴于大西洋鲑鱼加工废物的低价值利用，本研究侧重于开发一种使用酶促技术处理鲑鱼副产品的增值方法，并通过单因素实验和 Box-Behnken 设计优化水解参数，从而获得质量生产具有透明质酸酶抑制效率的肽。最佳参数为固液比1:14.793，胃蛋白酶添加量1.078%，酶解时间7.18 h。实际肽产量和抗透明质酸酶活性分别为 41.37% 和 63.23%。这为制备商业鲑鱼肽粉作为食品营养强化剂和透明质酸酶抑制剂在制药、保健和化妆品应用中的应用提供了参考。