Ageing and age-related diseases share some basic origin that largely converges on inflammation. Precisely, it boils down to a common pathway characterised by the appearance of a fair amount of proinflammatory cytokines known as inflammageing. Among the proposed treatment for antiageing, MSCs gained attention in recent years. Since mesenchymal stem cells (MSCs) can differentiate itself into a myriad of terminal cells, previously it was believed that these cells migrate to the site of injury and perform their therapeutic effect. However, with the more recent discovery of huge amounts of paracrine factors secreted by MSCs, it is now widely accepted that these cells do not engraft upon transplantation but rather unveil their benefits through excretion of bioactive molecules namely those involved in inflammatory and immunomodulatory activities. Conversely, the true function of these paracrine changes has not been thoroughly investigated all these years. Hence, this review will describe in detail on ways MSCs may capitalize its paracrine properties in modulating antiageing process. Through a comprehensive literature search various elements in the antiageing process, we aim to provide a novel treatment perspective of MSCs in antiageing related clinical conditions.

中文翻译：

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间充质干细胞在调节抗衰老过程中的潜在作用

衰老和与年龄有关的疾病有一些共同的基本起源，主要集中在炎症上。准确地说，它归结为一个共同的途径，其特征是出现大量称为炎症的促炎细胞因子。在提出的抗衰老治疗中，MSCs近年来受到关注。由于间充质干细胞 (MSCs) 可以将自身分化成无数的终末细胞，因此以前认为这些细胞会迁移到损伤部位并发挥其治疗作用。然而，随着最近发现 MSCs 分泌大量旁分泌因子，现在人们普遍认为这些细胞不会在移植后移植，而是通过分泌生物活性分子（即那些参与炎症和免疫调节活动的分子）来揭示它们的益处。相反，这些旁分泌变化的真正功能这些年来一直没有得到彻底的研究。因此，本综述将详细描述间充质干细胞如何利用其旁分泌特性调节抗衰老过程。通过对抗衰老过程中各种因素的全面文献检索，我们旨在为 MSCs 在抗衰老相关临床病症中的治疗提供新的视角。