Precisely how macrophages regulate response to immunotherapy remains unclear. In this issue of Cancer Cell, Chow et al. demonstrate a tumor-promoting role of TIM-4⁺ cavity macrophages which affects the response of metastatic malignancies to immunotherapy. Specifically, TIM-4⁺ macrophages engage with phosphatidylserine-expressing cytotoxic T lymphocytes, inhibiting their activity even during PD-1 blockade.

中文翻译：

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空腔巨噬细胞阻止抗肿瘤 T 细胞

巨噬细胞究竟如何调节对免疫疗法的反应仍不清楚。在本期的Cancer Cell中，Chow 等人。^{证明 TIM-4 +}腔巨噬细胞的肿瘤促进作用影响转移性恶性肿瘤对免疫疗法的反应。具体来说，TIM-4 ⁺巨噬细胞与表达磷脂酰丝氨酸的细胞毒性 T 淋巴细胞结合，即使在 PD-1 阻断期间也会抑制它们的活性。