Three articles in Nature show that intestinal stem cells with cancer-promoting mutations could shape the surrounding normal tissue in their favor to promote clonal fixation and field expansion, raising the possibility of developing therapeutic strategies that maintain or enhance the health of normal cells to out-compete the mutant cells.

中文翻译：

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致癌突变通过旁分泌重塑驱动肠癌发生

Nature 上的三篇文章表明，具有促癌突变的肠道干细胞可以塑造周围的正常组织，以促进克隆固定和场扩展，从而提高开发维持或增强正常细胞健康的治疗策略的可能性与突变细胞竞争。