Autophagy is a cytoprotective recycling mechanism, capable of digesting dysfunctional cellular components, and this process is associated with pro-survival outcomes. Autophagy may decline in the aging myocardium, thereby contributing to cardiac dysfunction. However, it remains to be established how autophagy responds to ischemia-reperfusion stress with age.

中文翻译：

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人类心脏缺血-再灌注损伤：随年龄增长的钝化应激反应

自噬是一种细胞保护性循环机制，能够消化功能失调的细胞成分，这一过程与促生存结果有关。衰老心肌中的自噬可能会下降，从而导致心功能不全。然而，随着年龄的增长，自噬如何对缺血再灌注应激做出反应还有待确定。