Biological aging is commonly associated with compromised cardiovascular function. In particular, cardiac aging is featured by unfavorable left ventricular remodeling, loss of compliance, and poor contractile reserve. Among possible contributing factors for cardiovascular aging, dampened autophagy response has received much attention. Recent evidence also noted a decline in ischemia-reperfusion (I/R) response and mitochondrial content in aging. I/R stress is commonly seen in the setting of cardiac surgery representing a clinical dilemma accompanied by possible myocardial injury if not handled correctly. Although overproduction of reactive oxygen species has been indicated to play a role in aging-associated more pronounced I/R injury, little is known for the mechanism of action (in particular the role of autophagy and mitophagy) and possible sequelae of poor I/R stress response in aging.

中文翻译：

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衰老是心脏手术的危险因素：缺血再灌注应激反应迟钝？

生物老化通常与心血管功能受损有关。特别是心脏老化的特点是不利的左心室重构、顺应性丧失和收缩储备差。在心血管衰老的可能影响因素中，自噬反应减弱受到了广泛关注。最近的证据还指出，随着衰老，缺血再灌注 (I/R) 反应和线粒体含量下降。I/R 应力常见于心脏手术环境中，代表一种临床困境，如果处理不当，可能会导致心肌损伤。尽管已表明活性氧的过度产生在与衰老相关的更明显的 I/R 损伤中起作用，