Disturbed mitochondrial redox state and tissue energy charge in cholestasis,Journal of Biochemical and Molecular Toxicology

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Disturbed mitochondrial redox state and tissue energy charge in cholestasis
Journal of Biochemical and Molecular Toxicology ( IF 3.2 ) Pub Date : 2021-07-12 , DOI: 10.1002/jbt.22846
Vahid Ghanbarinejad _{1,

2} , Mohammad M Ommati ₃ , Zhipeng Jia ₄ , Omid Farshad ₁ , Akram Jamshidzadeh _{1,

2} , Reza Heidari ₁

Affiliation

The liver is the primary organ affected by cholestasis. However, the brain, skeletal muscle, heart, and kidney are also severely influenced by cholestasis/cirrhosis. However, little is known about the molecular mechanisms of organ injury in cholestasis. The current study was designed to evaluate the mitochondrial glutathione redox state as a significant index in cell death. Moreover, tissue energy charge (EC) was calculated. Rats underwent bile duct ligation (BDL) and the brain, heart, liver, kidney, and skeletal muscle mitochondria were assessed at scheduled time intervals (3, 7, 14, and 28 days after BDL). A significant decrease in mitochondrial glutathione redox state and EC was detected in BDL animals. Moreover, disturbed mitochondrial indices were evident in different organs of BDL rats. These data could offer new insight into the mechanisms of organ injury and the source of oxidative stress during cholestasis and might provide novel therapeutic strategies against these complications.

中文翻译：

胆汁淤积中线粒体氧化还原状态和组织能量电荷的紊乱

肝脏是受胆汁淤积影响的主要器官。然而，胆汁淤积/肝硬化也会严重影响大脑、骨骼肌、心脏和肾脏。然而，关于胆汁淤积中器官损伤的分子机制知之甚少。目前的研究旨在评估线粒体谷胱甘肽氧化还原状态作为细胞死亡的重要指标。此外，计算了组织能量电荷（EC）。大鼠接受胆管结扎 (BDL)，并在预定的时间间隔（BDL 后 3、7、14 和 28 天）评估大脑、心脏、肝脏、肾脏和骨骼肌线粒体。在 BDL 动物中检测到线粒体谷胱甘肽氧化还原状态和 EC 显着降低。此外，在 BDL 大鼠的不同器官中，线粒体指数明显受到干扰。

更新日期：2021-09-15

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