Purpose: Comparing the efficacy and complications of microwave ablation (MA) combined with intensity-modulated radiation therapy (IMRT) and IMRT alone for locally advanced peripheral nonsmall-cell lung cancer (NSCLC).
Methods: Retrospective analysis was conducted on 76 patients with locally advanced peripheral NSCLC undergoing chemotherapy and metastatic lymph node radiation therapy from June 2014 to June 2016. Either MA or IMRT was used to treat primary lesions. Thirty-four cases were treated with MA (MA group), 42 cases were treated with IMRT (IMRT group), and comparisons were made of the 1–3-year progression-free survival (PFS) and complications of the two groups.
Results: The PFS of the MA group at 1, 2, and 3 years were 70.59% (24/34), 47.06% (16/34), and 35.29% (12/34), and the PFS of the IMRT group at the same intervals were 71.43% (30/42), 52.38% (22/42), and 35.71% (15/42), with no significant difference (χ² = 0.006, P = 0.936) (χ² = 0.213, P = 0.645) (χ² = 0.001, P = 0.970). Radiation-induced lung injury (RILI) occurred in 14.70% (5/34) of MA group patients, which was significantly lower than in the IMRT group 40.48% (17/42), but without grade II or above RILI.
Conclusion: MA combined with IMRT in the treatment of locally advanced peripheral NSCLC was not inferior to the clinical effect of radiation therapy alone, and radiation lung injury incidence was also lower.


中文翻译：

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微波消融联合放疗与单纯放疗治疗局部晚期非小细胞肺癌的疗效比较


目的：比较微波消融（MA）联合调强放射治疗（IMRT）和单独调强放疗（IMRT）治疗局部晚期周围型非小细胞肺癌（NSCLC）的疗效和并发症。
方法：回顾性分析2014年6月至2016年6月接受化疗和转移性淋巴结放疗的76例局部晚期外周NSCLC患者，采用MA或IMRT治疗原发灶。34例接受MA治疗（MA组），42例接受IMRT治疗（IMRT组），比较两组的1~3年无进展生存期（PFS）和并发症。
结果：MA组1、2、3年PFS分别为70.59%（24/34）、47.06%（16/34）、35.29%（12/34），IMRT组PFS相同区间分别为 71.43% (30/42)、52.38% (22/42) 和 35.71% (15/42)，差异无显着性 ( χ ² = 0.006, P = 0.936) ( χ ² = 0.213, P = 0.645 ) ( χ ² = 0.001, P = 0.970)。MA组患者发生放射性肺损伤（RILI）的发生率为14.70%（5/34），显着低于IMRT组的40.48%（17/42），但无II级或以上RILI。
结论： MA联合IMRT治疗局部晚期外周NSCLC的临床效果并不逊色于单纯放疗的临床效果，且放射性肺损伤发生率也较低。