Cardiovascular disease (CVD) is the leading cause of death worldwide. The most dangerous life-threatening symptoms of CVD are myocardial infarction and stroke. The causes of CVD are not entirely clear, and new therapeutic targets are still being sought. One of the factors involved in CVD development among vascular damage and oxidative stress is chronic inflammation. It is known that hyaluronic acid plays an important role in inflammation and is regulated by numerous stimuli, including proinflammatory cytokines. The main receptors for hyaluronic acid are CD44 and RHAMM. These receptors are membrane proteins that differ in structure, but it seems that they can perform similar or synergistic functions in many diseases. Both RHAMM and CD44 are involved in cell migration and wound healing. However, their close association with CVD is not fully understood. In this review, we describe the role of both receptors in CVD.

中文翻译：

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HMMR 和 CD44 介导的心血管效应

心血管疾病（CVD）是全球死亡的主要原因。心血管疾病最危险的威胁生命的症状是心肌梗塞和中风。CVD的病因尚不完全清楚，仍在寻找新的治疗靶点。血管损伤和氧化应激之间的 CVD 发展所涉及的因素之一是慢性炎症。众所周知，透明质酸在炎症中起重要作用，并受多种刺激因素的调节，包括促炎细胞因子。透明质酸的主要受体是 CD44 和 RHAMM。这些受体是结构不同的膜蛋白，但似乎它们可以在许多疾病中发挥相似或协同作用。RHAMM 和 CD44 都参与细胞迁移和伤口愈合。然而，它们与 CVD 的密切关系尚不完全清楚。在这篇综述中，我们描述了这两种受体在 CVD 中的作用。