Urologic cancers, comprising prostate carcinoma (PCa), renal cell carcinoma (RCC), and bladder carcinoma (BCa), were the commonly occurred carcinoma amid males. Long noncoding RNAs (lncRNAs) with the length of more than 200 nt functioned importantly in physiological and pathological advancement. Nevertheless, further investigation regarding lncRNA expression feature and function in urologic cancers should be essential. This study is aimed at uncovering the roles of the differently expressed lncRNAs in urologic cancers. The data of gene expression levels was downloaded from lncRNAtor datasets. The lncRNA expression pattern existing in different urologic cancers was assessed by hierarchical clustering analysis. Gene Ontology (GO) analysis and KEGG pathway analysis were separately applied to evaluate the biological function and process and the biological pathways involving differently expressed lncRNAs. Our results indicated that 18 lncRNA expressions were increased, and 16 lncRNA expressions were reduced in urologic cancers after comparison with that in normal tissues. Moreover, our results demonstrated 61, 422, 137, and 281 lncRNAs were specifically dysregulated in bladder cancer (BLCA), kidney renal clear cell cancer (KIRC), kidney renal papillary cell cancer (KIRP), and prostate adenocarcinoma (PRAD), respectively. Bioinformatics analysis showed that differently expressed lncRNAs displayed crucially in urologic cancers. The prognostic value of common and cancer-specific differently expressed lncRNAs, such as PVT1, in cancer outcomes, was emphasized here. Our research has deeply unearthed the mechanism of differently expressed lncRNAs in urologic cancers development.

中文翻译：

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泌尿系统癌症中常见和癌症特异性差异表达的 lncRNA 的综合表征

泌尿系统癌症，包括前列腺癌 (PCa)、肾细胞癌 (RCC) 和膀胱癌 (BCa)，是男性中最常见的癌症。长度超过 200 nt 的长链非编码 RNA (lncRNA) 在生理和病理进展中发挥重要作用。尽管如此，关于 lncRNA 在泌尿系统癌症中的表达特征和功能的进一步研究应该是必不可少的。本研究旨在揭示不同表达的 lncRNA 在泌尿系统癌症中的作用。从 lncRNAtor 数据集下载基因表达水平的数据。通过层次聚类分析评估存在于不同泌尿系统癌症中的 lncRNA 表达模式。分别应用基因本体（GO）分析和KEGG通路分析来评估涉及不同表达lncRNA的生物学功能和过程以及生物学通路。我们的结果表明，与正常组织相比，泌尿系统肿瘤中有 18 个 lncRNA 表达增加，16 个 lncRNA 表达减少。此外，我们的结果表明，61、422、137 和 281 个 lncRNA 分别在膀胱癌 (BLCA)、肾透明细胞癌 (KIRC)、肾乳头状细胞癌 (KIRP) 和前列腺腺癌 (PRAD) 中特异性失调. 生物信息学分析表明，不同表达的 lncRNA 在泌尿系统癌症中发挥着至关重要的作用。常见和癌症特异性不同表达的 lncRNA（如 PVT1）在癌症结果中的预后价值，这里强调了。我们的研究深入挖掘了不同表达的lncRNAs在泌尿系统肿瘤发展中的作用机制。