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Atherogenic index of plasma is related to coronary atherosclerotic disease in elderly individuals: a cross-sectional study
Lipids in Health and Disease ( IF 3.9 ) Pub Date : 2021-07-11 , DOI: 10.1186/s12944-021-01496-8
Haomin Huang 1 , Xiaolong Yu 2 , Lamei Li 1 , Ganwei Shi 1 , Feng Li 1 , Jianqiang Xiao 1 , Zhihua Yun 3 , Gaojun Cai 1
Affiliation  

Dyslipidaemia plays an important role in coronary atherosclerotic disease (CAD). The relationship between the atherogenic index of plasma (AIP) and CAD in elderly individuals was explored in this study. Elderly individuals (age ≥ 65 years) who underwent coronary angiography from January 2016 to October 2020 were consecutively enrolled in the study. A total of 1313 individuals, including 354 controls (non-CAD) and 959 CAD patients, were enrolled. In univariate analysis of all populations, the adjusted AIP (aAIP) in the CAD group was 1.13 (0.96, 1.3), which was significantly higher than that in the controls [1.07 (0.89, 1.26)]. However, in subgroup analyses, this phenomenon was only present in males. In addition, further study showed that aAIP was positively related to CAD severity. In binary logistic regression analyses, after adjusting for sex, age, smoking status, primary hypertension (PH), type 2 diabetes mellitus (T2DM), heart rate (HR), white blood cell (WBC) and platelet (PLT), AIP remained independently related to CAD in elderly individuals and was superior to traditional and other nontraditional lipid indices. Subgroup analyses showed that AIP independently influenced CAD risk in males. Ultimately, sensitivity analyses were performed excluding all coronary emergencies, and the final results were similar. AIP was positively related to the risk and severity of CAD in elderly individuals and was superior to traditional and other nontraditional lipid profiles. However, this association only exists in elderly males.

中文翻译:

血浆动脉粥样硬化指数与老年人冠状动脉粥样硬化疾病相关:一项横断面研究

血脂异常在冠状动脉粥样硬化疾病(CAD)中起重要作用。本研究探讨了老年人血浆动脉粥样硬化指数(AIP)与 CAD 之间的关系。2016 年 1 月至 2020 年 10 月期间接受冠状动脉造影的老年人(年龄 ≥ 65 岁)连续纳入研究。共纳入 1313 人,包括 354 名对照(非 CAD)和 959 名 CAD 患者。在所有人群的单变量分析中,CAD组的调整后AIP(aAIP)为1.13(0.96,1.3),显着高于对照组[1.07(0.89,1.26)]。然而,在亚组分析中,这种现象只存在于男性中。此外,进一步的研究表明,aAIP 与 CAD 严重程度呈正相关。在二元逻辑回归分析中,在调整性别后,年龄、吸烟状况、原发性高血压 (PH)、2 型糖尿病 (T2DM)、心率 (HR)、白细胞 (WBC) 和血小板 (PLT)、AIP 在老年人中仍然与 CAD 独立相关,并且优于传统和其他非传统的血脂指数。亚组分析表明,AIP 独立影响男性的 CAD 风险。最终,敏感性分析排除了所有冠状动脉紧急情况,最终结果相似。AIP 与老年人 CAD 的风险和严重程度呈正相关,并且优于传统和其他非传统血脂谱。然而,这种关联只存在于老年男性中。AIP 与老年人的 CAD 保持独立相关,并且优于传统和其他非传统血脂指数。亚组分析表明,AIP 独立影响男性的 CAD 风险。最终,敏感性分析排除了所有冠状动脉紧急情况,最终结果相似。AIP 与老年人 CAD 的风险和严重程度呈正相关,并且优于传统和其他非传统血脂谱。然而,这种关联只存在于老年男性中。AIP 与老年人的 CAD 保持独立相关,并且优于传统和其他非传统血脂指数。亚组分析表明,AIP 独立影响男性的 CAD 风险。最终,敏感性分析排除了所有冠状动脉紧急情况,最终结果相似。AIP 与老年人 CAD 的风险和严重程度呈正相关,并且优于传统和其他非传统血脂谱。然而,这种关联只存在于老年男性中。AIP 与老年人 CAD 的风险和严重程度呈正相关,并且优于传统和其他非传统血脂谱。然而,这种关联只存在于老年男性中。AIP 与老年人 CAD 的风险和严重程度呈正相关,并且优于传统和其他非传统血脂谱。然而,这种关联只存在于老年男性中。
更新日期:2021-07-12
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