Carcinogenesis is characterized by abnormal regulation of cell growth and cell death. IK is a novel cell mitosis regulator that may contribute to carcinogenesis. Previous studies showed that the loss of IK expression resulted in cell mitotic arrest and even cell death. Besides, IK can also inhibit the interferon gamma (IFN-γ)-induced expression of human leukocyte antigen (HLA) class II antigen, which is associated with tumour immune microenvironment. To gain insight into the current research progress regarding IK, we conducted a review and searched the limited literature on IK using PubMed or Web of Science. In this review, we discussed the possible biological functions and mechanisms of IK in cancer and its immune microenvironment. Future perspectives of IK were also mentioned to explore its clinical significance.

中文翻译：

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IK：一种有助于致癌的新型细胞有丝分裂调节剂

致癌作用的特征是细胞生长和细胞死亡的异常调节。IK 是一种新型的细胞有丝分裂调节剂，可能有助于致癌作用。先前的研究表明，IK 表达的丧失导致细胞有丝分裂停滞甚至细胞死亡。此外，IK 还可以抑制干扰素γ (IFN-γ) 诱导的人类白细胞抗原 (HLA) II 类抗原的表达，这与肿瘤免疫微环境有关。为了深入了解 IK 的当前研究进展，我们使用 PubMed 或 Web of Science 进行了审查并搜索了有关 IK 的有限文献。在这篇综述中，我们讨论了 IK 在癌症及其免疫微环境中可能的生物学功能和机制。还提到了 IK 的未来前景，以探讨其临床意义。