Recent Advances in Ionic Liquids in Biomedicine,Advanced Science

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Recent Advances in Ionic Liquids in Biomedicine
Advanced Science ( IF 14.3 ) Pub Date : 2021-07-10 , DOI: 10.1002/advs.202004819
Alexander M Curreri _{1,

2} , Samir Mitragotri _{1,

2} , Eden E L Tanner _{1,

3}

Affiliation

The use of ionic liquids and deep eutectic solvents in biomedical applications has grown dramatically in recent years due to their unique properties and their inherent tunability. This review will introduce ionic liquids and deep eutectics and discuss their biomedical applications, namely solubilization of drugs, creation of active pharmaceutical ingredients, delivery of pharmaceuticals through biological barriers, stabilization of proteins and other nucleic acids, antibacterial agents, and development of new biosensors. Current challenges and future outlooks are discussed, including biocompatibility, the potential impact of the presence of impurities, and the importance of understanding the microscopic interactions in ionic liquids in order to design task-specific solvents.

中文翻译：

离子液体在生物医学领域的最新进展

近年来，离子液体和低共熔溶剂由于其独特的性质和固有的可调性，在生物医学应用中的使用急剧增长。本综述将介绍离子液体和低共熔物，并讨论它们的生物医学应用，即药物的溶解、活性药物成分的创造、通过生物屏障的药物输送、蛋白质和其他核酸的稳定、抗菌剂以及新型生物传感器的开发。讨论了当前的挑战和未来的前景，包括生物相容性、杂质存在的潜在影响，以及了解离子液体中微观相互作用以设计特定任务溶剂的重要性。

更新日期：2021-09-09

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