Psychological interventions have been proven to be effective to prevent depression, however, little is known on the cost-effectiveness of psychological interventions for the prevention of depression in various populations.

A systematic review was conducted using PubMed, PsycINFO, Web of Science, Embase, Cochrane Central Register of Controlled Trials, Econlit, NHS Economic Evaluations Database, NHS Health Technology Assessment and OpenGrey up to January 2021. Only health-economic evaluations based on randomized controlled trials of psychological interventions to prevent depression were included. Independent evaluators selected studies, extracted data and assessed the quality using the Consensus on Health Economic Criteria and the Cochrane Risk of Bias Tool.

Twelve trial-based economic evaluations including 5929 participants from six different countries met the inclusion criteria. Overall, the quality of most economic evaluations was considered good, but some studies have some risk of bias. Setting the willingness-to-pay upper limit to US$40,000 (2018 prices) for gaining one quality adjusted life year (QALY), eight psychological preventive interventions were likely to be cost-effective compared to care as usual.

The likelihood of preventive psychological interventions being more cost-effective than care as usual looks promising, but more economic evaluations are needed to bridge the many gaps that remain in the evidence-base.

Ethics

As this systematic review is based on published data, approval from the local ethics committee was not required.

中文翻译：

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预防抑郁症的心理干预的健康经济评估：系统评价

心理干预已被证明可有效预防抑郁症，但是，关于心理干预在不同人群中预防抑郁症的成本效益知之甚少。

使用 PubMed、PsycINFO、Web of Science、Embase、Cochrane Central Register of Controlled Trials、Econlit、NHS 经济评估数据库、NHS 卫生技术评估和 OpenGrey 进行了系统评价，直至 2021 年 1 月。仅基于随机对照的健康经济评估包括预防抑郁症的心理干预试验。独立评估人员使用健康经济标准共识和 Cochrane 偏倚风险工具选择研究、提取数据并评估质量。

包括来自六个不同国家的 5929 名参与者在内的 12 项基于试验的经济评估符合纳入标准。总体而言，大多数经济评估的质量被认为是良好的，但一些研究存在一定的偏倚风险。将获得一个质量调整生命年 (QALY) 的支付意愿上限设置为 40,000 美元（2018 年价格），与常规护理相比，八种心理预防干预措施可能具有成本效益。

预防性心理干预比通常的护理更具成本效益的可能性看起来很有希望，但需要更多的经济评估来弥合证据基础中存在的许多差距。

伦理

由于本系统评价基于已发表的数据，因此不需要获得当地伦理委员会的批准。