Enamel does not contain living cells and thus is susceptible to damage that cannot be repaired by the human body. Artificial regeneration of these structures is theorized, but no widespread treatment of dental caries lesions has been developed. This review is an analysis of relevant techniques for the mineralization of hydroxyapatite (HAP) in enamel. Fluoride, amelogenin and its derivatives, peptide and amino acid treatments, surfactant and biogel templates, and direct crystal formation have been used with varying degrees of success to regenerate HAP structures. These methods are qualified by their ability to replicate HAP crystallites with enamel-like properties and of their possible application to clinical treatment.

牙釉质不含活细胞，因此容易受到人体无法修复的损伤。这些结构的人工再生是理论上的，但尚未开发出对龋齿病变的广泛治疗。本综述是对牙釉质中羟基磷灰石 (HAP) 矿化的相关技术的分析。氟化物、牙釉蛋白及其衍生物、肽和氨基酸处理、表面活性剂和生物凝胶模板以及直接晶体形成已在不同程度上成功用于再生 HAP 结构。这些方法通过它们复制具有釉质样特性的 HAP 微晶的能力以及它们在临床治疗中的可能应用的能力而合格。