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The influence of CYP2D6 and CYP2C19 genetic variation on diabetes mellitus risk in people taking antidepressants and antipsychotics
medRxiv - Psychiatry and Clinical Psychology Pub Date : 2021-08-16 , DOI: 10.1101/2021.07.07.21259926 Isabelle Austin-Zimmerman , Marta Wronska , Baihan Wang , Haritz Irizar , Johan Hilge Thygesen , Anjali Bhat , Spiros Denaxas , Ghazaleh Fatemifar , Chris Finan , Jasmine Harju-Seppänen , Olga Giannakopoulou , Karoline Kuchenbaecker , Eirini Zartaloudi , Andrew McQuillin , Elvira Bramon
medRxiv - Psychiatry and Clinical Psychology Pub Date : 2021-08-16 , DOI: 10.1101/2021.07.07.21259926 Isabelle Austin-Zimmerman , Marta Wronska , Baihan Wang , Haritz Irizar , Johan Hilge Thygesen , Anjali Bhat , Spiros Denaxas , Ghazaleh Fatemifar , Chris Finan , Jasmine Harju-Seppänen , Olga Giannakopoulou , Karoline Kuchenbaecker , Eirini Zartaloudi , Andrew McQuillin , Elvira Bramon
Background CYP2D6 and CYP2C19 enzymes are essential in the metabolism of antidepressants and antipsychotics. Genetic variation in these genes may increase risk of adverse drug reactions. Antidepressants and antipsychotics have previously been associated with risk of diabetes. We examined whether individual genetic differences in CYP2D6 and CYP2C19 contribute to these effects.
中文翻译：
CYP2D6和CYP2C19基因变异对服用抗抑郁药和抗精神病药人群糖尿病风险的影响
背景CYP2D6 和 CYP2C19 酶在抗抑郁药和抗精神病药的代谢中是必不可少的。这些基因的遗传变异可能会增加药物不良反应的风险。抗抑郁药和抗精神病药以前与糖尿病风险有关。我们检查了 CYP2D6 和 CYP2C19 的个体遗传差异是否导致这些影响。
更新日期：2021-08-19
中文翻译：
CYP2D6和CYP2C19基因变异对服用抗抑郁药和抗精神病药人群糖尿病风险的影响
背景CYP2D6 和 CYP2C19 酶在抗抑郁药和抗精神病药的代谢中是必不可少的。这些基因的遗传变异可能会增加药物不良反应的风险。抗抑郁药和抗精神病药以前与糖尿病风险有关。我们检查了 CYP2D6 和 CYP2C19 的个体遗传差异是否导致这些影响。
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