Hypnotizability, one's ability to experience cognitive, emotional, behavioral, and physical changes in response to suggestions in the context of hypnosis, is a highly stable trait associated with increased functional connectivity between the left dorsolateral prefrontal cortex (L-DLPFC) and dorsal anterior cingulate cortex (dACC). We conducted a preregistered, triple-blinded, randomized controlled trial to test the ability of continuous theta-burst stimulation (cTBS) over a personalized neuroimaging-based L-DLPFC target to temporarily enhance hypnotizability. We tested our hypothesis in 78 patients with fibromyalgia syndrome (FMS), a functional pain disorder for which hypnosis has consistently been shown to be beneficial as a nonpharmacological treatment option. Pre-to-post cTBS change in Hypnotic Induction Profile scores (HIP; a standardized measure of hypnotizability) was significantly greater in the Active versus Sham group. Our findings suggest a causal relationship between L-DLPFC and dACC function and hypnotizability. Dose-response optimization should be further examined to formalize guidelines for future clinical utilization.

中文翻译：

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使用重复经颅磁刺激调节稳定的神经行为特征：一项预先注册的随机对照试验

催眠能力，一个人在催眠背景下根据建议体验认知、情绪、行为和身体变化的能力，是一种高度稳定的特征，与左背外侧前额叶皮层 (L-DLPFC) 和背侧前扣带回之间的功能连接性增加有关皮层 (dACC)。我们进行了一项预先注册、三盲、随机对照试验，以测试基于个性化神经影像的 L-DLPFC 目标的连续 theta 爆发刺激 (cTBS) 暂时增强催眠能力的能力。我们在 78 名患有纤维肌痛综合征 (FMS) 的患者中测试了我们的假设，这是一种功能性疼痛疾病，催眠作为一种非药物治疗选择一直被证明是有益的。催眠诱导谱评分（HIP；催眠能力的标准化测量）在主动组与假组中显着更高。我们的研究结果表明 L-DLPFC 和 dACC 功能和催眠性之间存在因果关系。应进一步检查剂量反应优化，以制定未来临床应用的指南。