Menstrual pain has been associated with increased ovarian cancer risk, presumably through increased inflammation, which is known to play a critical role in ovarian carcinogenesis. Analgesic medications are frequently used to treat menstrual pain, some of which lower ovarian cancer risk. In this study, we examined the association between analgesic use for menstrual pain during the premenopausal period and ovarian cancer risk among women with history of menstrual pain. We used data from the New England Case-Control Study, including 1,187 epithelial ovarian cancer cases and 1,225 population-based controls enrolled between 1998 and 2008 with detailed information on analgesic use for their menstrual pain. We used unconditional logistic regression to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for the association between analgesic use (i.e., aspirin, ibuprofen, acetaminophen) for menstrual pain and ovarian cancer risk. We further conducted a stratified analysis by intensity of menstrual pain (mild/moderate, severe). Among women with menstrual pain during their 20s and 30s, ever use of analgesics for menstrual pain was not significantly associated with ovarian cancer risk. However, among women with severe menstrual pain, ever use of aspirin or acetaminophen for menstrual pain was inversely associated with risk (OR, 0.41; 95% CI, 0.18–0.94 and OR, 0.43; 95% CI, 0.21–0.88 compared with never users, respectively). No significant association was observed between analgesic use and ovarian cancer risk among women with mild/moderate menstrual pain ( P interaction ≤ 0.03). Our results suggest that use of aspirin or acetaminophen for severe menstrual pain may be associated with lower risk of ovarian cancer. Prevention Relevance: This study investigates whether analgesic use specifically for menstrual pain during the premenopausal period influences ovarian cancer risk. Our results suggest use of aspirin or acetaminophen for severe menstrual pain may be associated with lower risk of ovarian cancer among women with severe menstrual pain.

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经痛和卵巢癌风险的常见镇痛药

月经疼痛与卵巢癌风险增加有关，可能是通过增加炎症，已知炎症在卵巢癌发生中起关键作用。镇痛药常用于治疗经痛，其中一些可降低卵巢癌的风险。在这项研究中，我们检查了在绝经前期间使用镇痛剂治疗经痛与有经痛史的女性患卵巢癌风险之间的关系。我们使用了来自新英格兰病例对照研究的数据，其中包括 1998 年至 2008 年间登记的 1,187 例上皮性卵巢癌病例和 1,225 名基于人群的对照，并详细了解了使用镇痛剂治疗月经痛的情况。我们使用无条件逻辑回归来计算使用镇痛剂（即阿司匹林、布洛芬、对乙酰氨基酚）治疗月经痛与卵巢癌风险之间关联的优势比 (OR) 和 95% 置信区间 (CI)。我们进一步按月经疼痛的强度（轻度/中度、重度）进行了分层分析。在 20 多岁和 30 多岁出现月经痛的女性中，曾经使用镇痛剂治疗月经痛与卵巢癌风险没有显着相关性。然而，在患有严重经痛的女性中，曾经使用阿司匹林或对乙酰氨基酚治疗经痛与风险呈负相关（OR，0.41；95% CI，0.18-0.94 和 OR，0.43；95% CI，0.21-0.88，而从未使用过用户，分别）。在轻度/中度月经痛的女性中，镇痛药使用与卵巢癌风险之间没有显着相关性（P 交互作用 ≤ 0.03）。我们的研究结果表明，使用阿司匹林或对乙酰氨基酚治疗严重的经痛可能与卵巢癌风险降低有关。预防相关性：本研究调查了专门针对绝经前月经痛的镇痛药是否会影响卵巢癌风险。我们的研究结果表明，使用阿司匹林或对乙酰氨基酚治疗重度经痛可能与重度经痛女性患卵巢癌的风险降低有关。本研究调查了专门针对绝经前月经痛的镇痛药是否会影响卵巢癌的风险。我们的研究结果表明，使用阿司匹林或对乙酰氨基酚治疗重度经痛可能与重度经痛女性患卵巢癌的风险降低有关。本研究调查了专门针对绝经前月经痛的镇痛药是否会影响卵巢癌的风险。我们的研究结果表明，使用阿司匹林或对乙酰氨基酚治疗重度经痛可能与重度经痛女性患卵巢癌的风险降低有关。