Human coilin-interacting nuclear ATPase protein (hCINAP), also known as adenylate kinase 6 (AK6), is an atypical adenylate kinase with critical roles in many biological processes, including gene transcription, ribosome synthesis, cell metabolism, cell proliferation and apoptosis, DNA damage responses, and genome stability. Furthermore, hCINAP/AK6 dysfunction is associated with cancer and various inflammatory diseases. In this review, we summarize the structural features and biological roles of hCINAP in several important signaling pathways, as well as its connection with tumor onset and progression.

中文翻译：

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腺苷酸激酶 hCINAP/AK6 的独特结构特征及其在致癌和肿瘤进展中的多方面功能

人线圈蛋白相互作用核 ATP 酶蛋白 (hCINAP)，也称为腺苷酸激酶 6 (AK6)，是一种非典型腺苷酸激酶，在许多生物过程中发挥关键作用，包括基因转录、核糖体合成、细胞代谢、细胞增殖和凋亡、DNA损伤反应和基因组稳定性。此外，hCINAP/AK6 功能障碍与癌症和各种炎性疾病有关。在这篇综述中，我们总结了 hCINAP 在几个重要信号通路中的结构特征和生物学作用，以及它与肿瘤发生和进展的联系。