The optoelectronic properties of semiconductor nanoparticles make them valuable candidates for the long-term monitoring of transmembrane electric fields in excitable cells. In this work, we show that the electric field sensitivity of the fluorescence intensity of type-I and quasi-type-II quantum dots and quantum rods is enhanced under two-photon excitation compared to single-photon excitation. Based on the superior electric field sensitivity of the two-photon excited fluorescence, we demonstrate the ability of quantum dots and rods to track fast switching E-fields. These findings indicate the potential of semiconductor nanoparticles as cellular voltage probes in multiphoton imaging.

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量子点/棒双光子荧光增强的电场敏感性及其与细胞跨膜电压成像的相关性

半导体纳米粒子的光电特性使其成为长期监测可兴奋细胞中跨膜电场的有价值的候选者。在这项工作中，我们表明与单光子激发相比，在双光子激发下增强了 I 型和准 II 型量子点和量子棒的荧光强度的电场敏感性。基于双光子激发荧光的卓越电场敏感性，我们展示了量子点和量子棒跟踪快速切换电场的能力。这些发现表明半导体纳米粒子在多光子成像中作为细胞电压探针的潜力。