Lately, chemotherapy and photodynamic therapy (PDT) synergistic therapy has become a promising anti-cancer treatment mean. However, the hypoxia in tumor leads to huge impediments to the oxygen-dependent PDT effects. In this work, a multifunctional nanoplatform (TUDMP) based on a multivariable porphyrin-nMOFs core and a manganese dioxide (MnO₂) shell was prepared for relieving tumor hypoxia and enhancing chemo-photodynamic synergistic therapy performance. The obtained TUDMP nanoplatform could effectively catalyze the hydrolysis of hydrogen peroxide to generate oxygen and also lead to consumption of antioxidant GSH, thereby facilitating the production of cytotoxic reactive oxygen species (ROS) by photosensitizer under laser irradiation. More importantly, the decomposition of the MnO₂ shell would further promote the release of the loaded doxorubicin (DOX), and thus an efficient chemo-PDT synergistic therapy was realized. Both in vitro and in vivo experimental results demonstrated the oxygen self-sufficient multifunctional nanoplatform could exhibit significantly enhanced anticancer efficiencies compared with chemotherapy or PDT alone.

近年来，化学疗法和光动力疗法（PDT）的协同疗法已成为一种很有前途的抗癌治疗手段。然而，肿瘤中的缺氧导致了对氧依赖性PDT作用的巨大障碍。在这项工作中，制备了一种基于多变量卟啉-nMOFs核和二氧化锰（MnO ₂）壳的多功能纳米平台（TUDMP），用于缓解肿瘤缺氧并提高化学-光动力协同治疗性能。所获得的TUDMP纳米平台可以有效催化过氧化氢水解产生氧气，并导致抗氧化剂GSH的消耗，从而促进光敏剂在激光照射下产生细胞毒性活性氧（ROS）。更重要的是，MnO _2的分解shell将进一步促进负载的多柔比星（DOX）的释放，从而实现高效的化学-PDT协同治疗。体外和体内实验结果表明，与单独的化疗或 PDT 相比，氧气自给自足的多功能纳米平台可以表现出显着提高的抗癌效率。