Epithelial to mesenchymal transition (EMT) is a biological process that plays an important role during embryonic development. During this process, the epithelial cells lose their polarity and acquire mesenchymal properties. In addition to embryonic development, EMT is also well-known to participate in tissue repair, inflammation, fibrosis, and tumor metastasis. In the present review, we address the basics of epithelial to mesenchymal transition during both development and disease conditions and emphasize the role of various transcription factors and miRNAs involved in the process.

中文翻译：

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上皮间质转化的分子机制

上皮间质转化 (EMT) 是一种在胚胎发育过程中发挥重要作用的生物学过程。在此过程中，上皮细胞失去极性并获得间充质特性。除了胚胎发育，众所周知，EMT 还参与组织修复、炎症、纤维化和肿瘤转移。在本综述中，我们讨论了发育和疾病条件下上皮到间充质转化的基础知识，并强调了参与该过程的各种转录因子和 miRNA 的作用。