R-loops—nucleic acid structures composed of an RNA:DNA hybrid and displaced single-stranded DNA—are abundant in the genome and may impair progression of the replication fork, thus leading to accumulation of DNA damage and genome instability. A new study demonstrates that SWI/SNF chromatin-remodeling complexes are instrumental in resolving such R-loop-mediated transcription–replication conflicts, highlighting the importance of these chromatin remodelers in R-loop homeostasis and the maintenance of genome integrity.

中文翻译：

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SWI/SNF 复合物作为 R 环代谢的决定因素

R 环——由 RNA:DNA 杂合体和置换的单链 DNA 组成的核酸结构——在基因组中含量丰富，可能会损害复制叉的进程，从而导致 DNA 损伤的积累和基因组的不稳定性。一项新的研究表明，SWI/SNF 染色质重塑复合物有助于解决这种 R 环介导的转录-复制冲突，突出了这些染色质重塑剂在 R 环稳态和维持基因组完整性中的重要性。