Neutrophil–T cell crosstalk in inflammatory bowel disease,Immunology

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Neutrophil–T cell crosstalk in inflammatory bowel disease
Immunology ( IF 4.9 ) Pub Date : 2021-07-08 , DOI: 10.1111/imm.13391
Egle Kvedaraite _{1,

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Affiliation

Neutrophils are the most abundant leucocytes in human blood, promptly recruited to the site of tissue injury, where they orchestrate inflammation and tissue repair. The multifaceted functions of neutrophils have been more appreciated during the recent decade, and these cells are now recognized as sophisticated and essential players in infection, cancer and chronic inflammatory diseases. Consequently, our understanding of the role of neutrophils in inflammatory bowel disease (IBD), their immune responses and their ability to shape adaptive immunity in the gut have been recognized. Here, current knowledge on neutrophil responses in IBD and their capacity to influence T cells are summarized with an emphasis on the role of these cells in human disease.

中文翻译：

炎症性肠病中的中性粒细胞-T细胞串扰

中性粒细胞是人类血液中最丰富的白细胞，会迅速被招募到组织损伤部位，在那里它们协调炎症和组织修复。近十年来，中性粒细胞的多方面功能得到了更多的重视，这些细胞现在被认为是感染、癌症和慢性炎症疾病的复杂和必不可少的参与者。因此，我们对中性粒细胞在炎症性肠病 (IBD) 中的作用、它们的免疫反应和它们在肠道中形成适应性免疫的能力的理解已经得到认可。在这里，对 IBD 中性粒细胞反应及其影响 T 细胞的能力的当前知识进行了总结，重点是这些细胞在人类疾病中的作用。

更新日期：2021-07-08

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