Background: Excess body weight (EBW) is a risk factor for various acute and chronic conditions. Conversely, the “obesity paradox” suggests a protective effect of higher body weight on some disease outcomes. This article discusses the role of EBW along the disease continuum of pancreatitis and pancreatic cancer (PC) in terms of incidence and outcome. Summary: Comparison of findings is hampered by the use of different methods to assess EBW. Nevertheless, in acute pancreatitis (AP) and PC, EBW, especially visceral obesity, presents a distinct risk factor and predictor of a negative outcome. Findings of a protective effect likely result from nonconsideration of fat distribution or other confounders. Regarding chronic pancreatitis (CP), few studies indicate lower incidence and a better outcome with higher body mass. However, there is insufficient evidence to confirm the existence of an obesity paradox. The precise mechanisms of how EBW affects the disease continuum require further elucidation but both common and disease-specific effects seem involved. Key Messages: EBW is associated with higher incidence and a negative outcome in AP and PC. The association with CP is less conclusive. Thus, maintaining normal weight is advisable at any stage of the disease continuum.
Visc Med

中文翻译：

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超重和胰腺疾病

背景：超重 (EBW) 是各种急性和慢性疾病的危险因素。相反，“肥胖悖论”表明较高的体重对某些疾病结果具有保护作用。本文讨论了 EBW 在胰腺炎和胰腺癌 (PC) 疾病连续体中的发病率和结果方面的作用。概括：使用不同的方法评估 EBW 阻碍了结果的比较。然而，在急性胰腺炎 (AP) 和 PC 中，EBW，尤其是内脏肥胖，是一个明显的危险因素和负面结果的预测因素。保护作用的发现可能是由于没有考虑脂肪分布或其他混杂因素。关于慢性胰腺炎 (CP)，很少有研究表明发病率较低且体重较高时预后较好。然而，没有足够的证据证实肥胖悖论的存在。EBW 如何影响疾病连续性的确切机制需要进一步阐明，但似乎涉及常见和疾病特异性影响。关键信息：EBW 与 AP 和 PC 的较高发病率和负面结果相关。与 CP 的关联不太确定。因此，建议在疾病连续体的任何阶段保持正常体重。
粘性医学