Using bromopyridines and methoxyphenyl boronic acid as starting materials, consecutive Suzuki-Miyaura cross-coupling and hydrogenation reactions were undertaken using a heterogeneous Pd/C catalyst in one-pot manner under mild conditions (balloon-pressure at room temperature for hydrogenation) with excellent yield. To counter Pd leaching as well as catalyst poisoning, addition of an appropriate amount of H₂O was crucial to achieving successful AcOH-promoted hydrogenation, which ensured a selective reduction of the pyridine rings to the corresponding piperidines.

中文翻译：

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Pd/C 催化的一锅 Suzuki-Miyaura 交叉偶联/氢化吡啶衍生物

以溴代吡啶和甲氧基苯基硼酸为原料，在温和条件（室温气球压力加氢）下，使用多相Pd/C催化剂以一锅法进行连续的Suzuki-Miyaura交叉偶联和加氢反应，收率优异. 为了防止 Pd 浸出和催化剂中毒，添加适量的 H ₂ O 对于成功实现 AcOH 促进的氢化至关重要，这确保了吡啶环选择性还原为相应的哌啶。