Synthesis of (s)-1-{3-[4-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmetyl}-3-substituted-urea derivatives as antibacterial agents,Journal of Heterocyclic Chemistry

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Synthesis of (s)-1-{3-[4-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmetyl}-3-substituted-urea derivatives as antibacterial agents
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2021-07-09 , DOI: 10.1002/jhet.4342
Mukunda R. Patekar ₁ , Vijay J. Medhane _{1,

2} , Ghanshyam R. Jadhav ₁ , Mayur J. Thakare ₃ , Dattatray G. Deshmukh ₁

Affiliation

A new series of (s)-1-{3-[4-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmetyl}-3-substituted-urea derivatives have been synthesized and characterized with spectral data, such as IR, NMR and Mass spectroscopies. All compounds are in vitro evaluated for their efficacy as antimicrobial agent against the gram-positive pathogenic strains such as Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 25923, Staphylococcus epidermidis ATCC 12228 and Streptococcus pyogens ATCC 8668. Five compounds (19k, 19l, 19m, 19n and 19o) out of 15 compounds showed moderate activity.

中文翻译：

(s)-1-{3-[4-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmetyl的合成}-3-取代脲衍生物作为抗菌剂

(s)-1-{3-[4-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5 新系列-ylmetyl}-3-取代的脲衍生物已经合成并用光谱数据表征，如红外、核磁共振和质谱。所有化合物都在体外评估了它们作为抗菌剂对抗革兰氏阳性病原菌株的功效，例如枯草芽孢杆菌 ATCC 6633、金黄色葡萄球菌 ATCC 25923、表皮葡萄球菌 ATCC 12228和化脓链球菌 ATCC 8668。五种化合物（19k、19l、19m、19n和19o) 有 15 种化合物表现出中等活性。

更新日期：2021-07-09

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