Advanced age is associated with a decline in response to stress. This contributes to the establishment of chronic inflammation, one of the hallmarks of aging and age-related disease. Heat shock proteins (HSP) are determinants of life span, and their progressive malfunction leads to age-related pathology. To discuss the function of HSP on age-related chronic inflammation and illness. An updated review of literature and discussion of relevant work on the topic of HSP in normal aging and chronic inflammatory pathology was performed. HSP contribute to inflamm-aging. They also play a key role in age-associated pathology linked to chronic inflammation such as autoimmune disorders, neurological disease, cardiovascular disorder, and cancer. HSP may be targeted for control of their effects related to age and chronic inflammation. Research on HSP functions in age-linked chronic inflammatory disorders provides an opportunity to improve health span and delay age-related chronic disorders.

高龄与对压力的反应下降有关。这有助于建立慢性炎症，这是衰老和年龄相关疾病的标志之一。热休克蛋白 (HSP) 是寿命的决定因素，其进行性故障会导致与年龄相关的病理。探讨HSP对年龄相关性慢性炎症和疾病的作用。对正常衰老和慢性炎症病理学中的 HSP 主题进行了更新的文献回顾和相关工作的讨论。HSP 有助于炎症老化。它们还在与慢性炎症相关的年龄相关病理学中发挥关键作用，例如自身免疫性疾病、神经系统疾病、心血管疾病和癌症。HSP 可以作为控制其与年龄和慢性炎症相关的影响的目标。