Bioactive principles from various natural resources including medicinal herbs have always played a crucial role in healthcare settings and increasingly became key players in drug discovery and development for many biopharmaceutical applications. Additionally, natural products (NPs) have immense arrangement of distinctive chemical structures with diverse functional groups that motivated numerous investigators including synthetic chemists to discover new therapeutic entities. Numerous pre-clinical investigations involving the animal models have evident the usefulness of these NPs against various human diseases including neurodegenerative disorders (NDs). Ocimum basilicum Linn (O. basilicum L.), also known as sweet basil, is well practiced in traditional healthcare systems and has been used to treat various human illnesses, which include malaria, skin disease, diarrhea, bronchitis, dysentery, arthritis, eye diseases, and insect bites and emphasize the significance of the ethno-botanical approach as a potential source of novel drug leads With the growing interest in advanced techniques, herbal medicine and medicinal plants explorations are still considered to be a novel resource for new pharmacotherapeutic discovery and development. O. basilicum L and its bioactive principles including apigenin, eugenol, myretenal, β-sitosterol, luteolin, rosmarinic acid, carnosic acid, essential oil (EO)-rich phenolic compounds, and others like anthocyanins and flavones could be of therapeutic values in NDs by exhibiting their neuro-protective efficacy on various signaling pathways. The present comprehensive review collected various related information using the following searching engines such as PubMed, Science Direct, Google Scholar, etc. and focused mainly the English written documents. The search period comprised of last two decades until present. Although these efficacious plant genera of prime importance and has potential medical and socioeconomic importance, yet the pivotal evidence for its neuroprotective potential in novel clinical trials remains lacking. However, with the available wealth of obtainable literature on this medicinal plant, which supports this review and concludes that O. basilicum L may function as a promising therapeutics for the treatment of NDs.

中文翻译：

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罗勒的神经保护作用：神经退行性疾病的预防和管理综述

来自包括药材在内的各种自然资源的生物活性成分一直在医疗保健环境中发挥着至关重要的作用，并且越来越成为许多生物制药应用的药物发现和开发的关键参与者。此外，天然产物 (NP) 具有大量不同官能团的独特化学结构，这促使包括合成化学家在内的众多研究人员发现新的治疗实体。许多涉及动物模型的临床前研究已经证明这些 NPs 对各种人类疾病的有用性，包括神经退行性疾病 (NDs)。Ocimum basilicum Linn (O. basilicum L.)，也被称为甜罗勒，在传统医疗保健系统中得到广泛应用，并已被用于治疗各种人类疾病，包括疟疾、皮肤病、腹泻、支气管炎、痢疾、关节炎、眼病和昆虫叮咬，并强调民族植物学方法作为新药潜在来源的重要性随着对先进技术的兴趣日益浓厚，草药和药用植物的探索正在仍然被认为是新药物治疗发现和开发的新资源。O. basilicum L 及其生物活性成分，包括芹菜素、丁子香酚、肉豆蔻醛、β-谷甾醇、木犀草素、迷迭香酸、鼠尾草酸、富含精​​油 (EO) 的酚类化合物，以及其他如花青素和黄酮，可能对 ND 具有治疗价值通过在各种信号通路上展示它们的神经保护功效。本综合综述使用以下搜索引擎收集了各种相关信息，例如 PubMed、Science Direct、Google Scholar 等，主要关注英文书面文件。搜索期包括过去二十年直到现在。尽管这些有效的植物属具有重要意义并具有潜在的医学和社会经济重要性，但在新的临床试验中仍缺乏其神经保护潜力的关键证据。然而，根据关于这种药用植物的大量可用文献，支持本综述并得出结论，O. basilicum L 可能作为治疗 NDs 的一种有前途的疗法。然而，在新的临床试验中，其神经保护潜力的关键证据仍然缺乏。然而，根据关于这种药用植物的大量可用文献，支持本综述并得出结论，O. basilicum L 可能作为治疗 NDs 的一种有前途的疗法。然而，在新的临床试验中，其神经保护潜力的关键证据仍然缺乏。然而，根据关于这种药用植物的大量可用文献，支持本综述并得出结论，O. basilicum L 可能作为治疗 NDs 的一种有前途的疗法。