Purpose

The Primavera is considered amongst the greatest and controversial artistic masterpieces worldwide painted by renaissance artist Sandro Botticelli. The aim was to identify any underlying medical foundations for the painting.

Methods

Observational study.

Results

The painting reveals, a ‘butterfly’ malar rash, bilateral ptosis and a clear neck swelling consistent with a goitre in the figure of Flora. This could be explained by concomitant Graves’ disease and systemic lupus erythematosus, or other presentations of multiple autoimmune syndrome.

Conclusion

These findings highlight the likely presentation of the earliest pictorial depictions of thyroid disease with systemic lupus erythematosus and emphasize the exactitude of depiction demonstrated by Botticelli in renaissance era.

中文翻译：

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Sandro Botticelli (1445-1510) 对初生区菌群的甲状腺肿块、面部颧骨皮疹和上睑下垂的鉴别诊断

目的

Primavera 被认为是文艺复兴时期艺术家 Sandro Botticelli 绘制的全球最伟大和有争议的艺术杰作之一。目的是确定这幅画的任何潜在医学基础。

方法

观察性研究。

结果

这幅画显示，“蝴蝶状”颧骨皮疹、双侧上睑下垂和明显的颈部肿胀，与弗洛拉图中的甲状腺肿一致。这可以通过伴随的格雷夫斯病和系统性红斑狼疮或多种自身免疫综合征的其他表现来解释。

结论

这些发现突出了对甲状腺疾病伴系统性红斑狼疮的最早图像描述的可能表现，并强调了文艺复兴时期波提切利所展示的描述的准确性。