The intracellular long-range transport of membrane vesicles and organelles is mediated by microtubule motors (kinesins, dynein) which move cargo with spatiotemporal accuracy and efficiency. How motors navigate the microtubule network and coordinate their activity on membrane cargo are fundamental but poorly understood questions. New studies show that microtubule-dependent membrane traffic is spatially controlled by septins – a unique family of multimerizing GTPases that associate with microtubules and membrane organelles. We review how septins selectively regulate motor interactions with microtubules and membrane cargo. We posit that septins provide a novel traffic code that specifies the movement and directionality of select motor–cargo complexes on distinct microtubule tracks.

膜囊泡和细胞器的细胞内远程运输由微管马达（驱动蛋白、动力蛋白）介导，微管马达以时空准确性和效率移动货物。马达如何在微管网络中导航并协调它们在膜货物上的活动是基本但知之甚少的问题。新的研究表明，依赖于微管的膜交通在空间上由败血症控制，败血症是一种独特的多聚化 GTP 酶家族，与微管和膜细胞器相关。我们回顾了败血症如何选择性地调节与微管和膜货物的运动相互作用。我们假设 septins 提供了一种新的交通代码，它指定了不同微管轨道上选定的机动货物复合体的运动和方向性。