A unique specimen of argyria is preserved in the Morgagni Museum of Pathological Anatomy at the University of Padua (Italy). It is a stuffed head belonging to a man who decided to cure his syphilis by himself with the so-called infernal stone (silver nitrate) every day for years, thus developing argyria in the second half of the nineteenth century. Paleopathological and historical studies were performed on the specimen to confirm the diagnosis of argyria. Furthermore, a morphological investigation of the specimen was conducted with histological and ultrastructural investigations, including environmental scanning electron microscopy and electron dispersive x‐ray spectroscopy, recording high presence of silver in the dermis and epidermis and also other chemical elements correlated to the “infernal stone.” A comparison with actual cases may also lead to a common feature: a potential dependence on the perceived benefits brought by silver compound that may sustain a further prolonged intake.

帕多瓦大学（意大利）的莫尔加尼病理解剖博物馆保存了一个独特的银银花标本。这是一个人的脑袋，他决定多年来每天用所谓的地狱石（硝酸银）自己治愈他的梅毒，从而在 19 世纪下半叶发展了银屑病。对标本进行了古病理学和历史研究，以确认银屑病的诊断。此外，通过组织学和超微结构研究对标本进行了形态学研究，包括环境扫描电子显微镜和电子色散 X 射线光谱，记录了真皮和表皮中大量存在的银以及与“地狱石”相关的其他化学元素.